Management of cervical dysplasia in HIV positive women | ICRH

TEAM MEMBERS 

PERIOD 

PARTNERS

• Dr Othigo, Coast Provincial General Hospital Mombasa
• J Bogers, E Van Marck, University Antwerp
• Chris Verhofstede, AIDS Reference Laboratory, Ghent University

OBJECTIVES

• To assess the effectiveness of outpatient management of precancerous lesions of the cervix in HIV positive women and to identify predictors for progression

METHODS

• A total of 75 HIV positive women with abnormal cytology will be included in the study
• After informed consent, a colposcopy is done, a biopsy, and genital sampling for viral tests
• Women with a high grade dysplasia are treated with loop electrical excision procedure; women with histological confirmed CIN 1 are not treated but receive follow-up
• Follow-up visits are planned for all women at 6 and 12 months

ACTIVTIES

• Until now, 75 women have been included in the study
• Of these women, 20 had a CIN1, 32 a CIN2/3 and 1 had an invasive carcinoma
• Follow up of the cohort is ongoing

EXPECTED RESULTS

• Distribution of HPV in HIV positve women
• Information on HPV types and viral load in HIV positive women with precancerous lesions of the cervix, before and after treatment
• Recurrence and progress rate after treatment of high grade lesions
• Progression rate of low grade lesions